Topic
8 posts
2026-08-30
How to tell demo-ware from deployable agentic AI in clinical trials: determinism, audit trails, 21 CFR Part 11, constrained architectures, and vendor questions.
#llm-agents#clinical-trials#gxp#audit-trail#agent-architecture
2026-08-30
A tiered survey of LLM evidence in clinical trial statistical programming: benchmarked results, promising single-team studies, vendor hype, and open gaps for 2026–2027.
#llm#clinical-trials#statistical-programming#survey#benchmarks#gxp
2026-08-25
Independent QC re-programming costs 30–50% of clinical programming effort. An AI framework matched 97.1–100% of variables while keeping independence intact.
2026-08-22
Five LLM generation methods benchmarked across 1,999 bootstrap experiments on ICH E3-conformant TLF templates: hybrid RAG with reranking beats direct prompting.
#rag#llm-benchmarking#tlf-templates#clinical-trials#r-code-generation
2026-08-20
Free-form agent loops break down in GxP clinical programming. Structuring the work as a typed process DAG makes LLM agents reliable, replayable, and auditable.
2026-08-19
A GRADE-rated review of 2020–2025 automation evidence in statistical programming: real gains, mostly Low to Very Low quality evidence.
#statistical-programming#automation#evidence-quality#clinical-trials
2026-08-16
A bridge map, typed IR, and orchestrator wrap a legacy SAS TFL library unchanged — AI-ready JSON on day one, 80%+ cell-level parity, optional 92% code cut.
#sas#legacy-modernization#clinical-trials#llm-integration#statistical-programming
2026-08-13
ClinAgent splits clinical programming capability into five layers, keeping MCP tools stateless and packaging domain expertise as testable skills.
#llm-agents#mcp#clinical-trials#statistical-programming#agent-architecture