2026-08-30
CDISC CORE Explained: Open-Source Validation for SDTM/ADaM Programmers
CDISC CORE is a free, open-source rule engine for SDTM and ADaM validation. How its YAML rules work, how to run it, and where rule-based checking stops.
Topic
#adam
4 posts
2026-08-25
Double Programming Without the Duplication: AI-Generated QC Code
Independent QC re-programming costs 30–50% of clinical programming effort. An AI framework matched 97.1–100% of variables while keeping independence intact.
2026-08-10
Synthetic ADaM That Survives a Join: Knowledge Graphs, LLMs, Faker
Schema-only synthetic ADaM generation plateaus at 0.45 overall quality; enriching schemas from protocol/SAP/CRF knowledge graphs plus templates reaches 0.70.
#synthetic-data#adam#knowledge-graphs#llm#statistical-programming
2026-08-07
Fine-Tuning Llama 3.1 8B for admiral R Code: From 0.36 to 0.82
Base Llama 3.1 8B scores 0.36 on admiral code generation. LoRA fine-tuning plus knowledge-graph validation gets it to 0.82 — without sending data to an API.