2026-08-30
CDISC CORE Explained: Open-Source Validation for SDTM/ADaM Programmers
CDISC CORE is a free, open-source rule engine for SDTM and ADaM validation. How its YAML rules work, how to run it, and where rule-based checking stops.
Topic
#sdtm
3 posts
2026-08-30
One Number That Explains Where Rule-Based Validation Stops
69.7% of oncology CORE rules port cleanly to a graph constraint language. The 30% that don't are exactly where the dangerous errors live.
2026-08-27
The Contradictions Your Validator Can't See
Rule-based SDTM validators structurally miss cross-domain contradictions. SHACL-SPARQL graph constraints plus a deterministic agent layer catch all 20 archetypes.